WET GRANULATION PROCESS

Wet granulation forms by binding the powder together with an adhesive, instead of by compaction, bridges are developed between the particles and the tensile strength of bonds increases as amount of liquid added is increased.

Wet granulation involved the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent which can be removed by drying, and should be non-toxic. Typical solvents include

PHARMACEUTICAL EXCIPIENTS

Ø  Excipients are those substances which are added to the formulation other than pharmacological active drug

Ø  Excipients have slight or no action and added to formulation to get the desire properties.

Ø  According to IPEC “Excipients are those product having slight or no action and intended to added in formulation to make formulation more effective.

PRODUCTION TECHNIQUES & SCALE-UP TECHNIQUES

INTRODUCTION:

1.       RESEARCH AND DEVELOPMENT PERSONNEL EXPAND A CONSIDERABLE AMOUNT OF EFFORT DEVELOPING DRUG DOSAGE FORMS WITH EXACTING SPECIFICATIONS (ADEQUATE PHYSICAL&CHEMICAL STABILITIES).

2.       SCALE UP TECHNIQUES MUST INCLUDE A CLOSE EXAMINATION OF THE FORMULA TO DETERMINE ITS ABILITY TO WITH STAND BATCH SCALE AND PROCESS MODIFICATION.